Genomic Analysis Core

Director: Tapan Ganguly, PhD

The Genomic Analysis Core combines the expertise and instrumentation of two facilities, the DNA Sequencing Facility and the Genomics Facility, to provide an integrated array of services for DNA sequencing and molecular profiling. Tapan Ganguly, PhD, the Director of the DNA Sequencing Facility since 2003, is the Director of the consolidated Core. The integration of the two Shared Resources provides more efficient access and clarity of technologies to Abramson Cancer Center (ACC) members. A team of highly experienced and trained professionals provides a whole spectrum of genomic and molecular biological services. These services are essential to ACC members for studying the role of specific genes in normal or abnormal cellular processes found in cancer cells and tumors. Investigators are able to observe global gene expression pattern in a sample, and genetic variability in an unaffected or tumor genome.

Contact

Tapan Ganguly, PhD
Phone: 215-573-7238
gangulyt@mail.med.upenn.edu

DNA Sequencing Services

Sequencing Services

  • Sanger Sequencing
  • Next-Generation sequencing on Ion Torrent PGM and Proton
  • Microsatellite-based Genotyping & Fragment Analysis

Molecular Biological Services

  • PCR, Cloning, Sub-cloning, Mutagenesis, Gene Targeting Constructs

Genomics Services

SNP Genotyping

  • 1 or more SNPs on ABI QS12K FLEX
  • 24 or more SNPs on Fluidigm BioMark HD
  • 900K SNPs & 1M CNV probes on Affymetrix platform
  • 650K SNPs, 96 samples on Gene Titan (Affymetrix)

Gene Expression

  • 1 or more genes on ABI QS12K FLEX
  • 3 or more genes, 96 samples on Luminex
  • 24 or more genes, 96 samples on Fluidigm
  • Whole transcriptome on Affymetrix platform
  • Transcriptome, 96 samples on Gene Titan (Affymetrix)

For more information, please visit the Core's website: http://www.med.upenn.edu/genetics/dnaseq/