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Alexander Perl, MD

Alexander Perl, MD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Perl is a Penn Medicine employed physician.

Clinical Specialties


  • Medicine
    • Hematology
    • Medical Oncology

Programs & Services:

  • Cancer
    • Bone Marrow Transplant and Stem Cell Transplant Program
    • Leukemia
  • Hematology
    • Classical (Non-Malignant) Hematology Program

Board Certification:

  • Medical Oncology, 2003

Conditions & Treatments:

  • acute leukemia
  • Acute Lymphocytic Leukemia in Adults (ALL)
  • Acute Myeloid Leukemia (AML)
  • Blood Cancer
  • Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
  • chronic myelogenous leukemia
  • Chronic Myeloid Leukemia (CML)
  • Leukemia
  • myelodysplasia
  • Myeloproliferative Neoplams (MPN)

Clinical Interests

Dr. Perl specializes in the care of patients with acute leukemia (AML and ALL), myelodysplastic syndromes (MDS), and CML.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Mount Sinai School of Medicine
Residency: UCSF Medical Center and Hospital
Fellowship: Johns Hopkins Hospital


American Association for Cancer Research, National American Society of Clinical Oncology, National American Society of Hematology, National


Dr. Perl is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Research Interests:

Dr. Perl studies oncogenic signal transduction in acute myelogenous leukemia. His research focuses upon the phosphotidyl inositol 3' kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway as well as the Fms-like Tyrosine Kinase 3 (FLT3). He has designed and performed clinical trials examining the strategy of inhibiting mTOR to promote chemotherapy response in AML as well as FLT3 inhibitors to treat patients with kinase activating FLT3 mutations. Laboratory correlation science on these studies was also performed by Dr. Perl, leading to improved methods for measuring mTOR activation in clinical samples via phospho-specific flow cytometry of fixed, unfractionated blood and marrow. Dr. Perl is currently exploring the use of flow cytometry for pharmacodynamic monitoring of signal transduction inhibitor response in hematologic malignancies as well as preclinical drug screening in cellular and murine xenotransplantation models.

Academic Contact Info

709 BRB 2/3
421 Curie Blvd

Philadelphia, PA 19104
Phone: (215) 573-8478
Fax: (215) 573-7049
Patient appointments: 800-789-PENN (7366)

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