My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
My clinical research focuses on using hypofractionated radiation to potentiate the action of immune checkpoint inhibitors in patient with metastatic solid tumors including melanoma, non small-lung cancer, and breast cancer.
Gandhi SJ, Minn A, Vonderheide RH, Wherry EJ, Hahn SM, Maity A: Awakening the immune system with radiation: Optimal dose and fractionation. Cancer letters : 2015.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ: Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature : 2015.
Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio N, Tuttle S, Busch TM, Lin A, Esipova TV, Vinogradov SA, Koumenis C, Maity A: PI3K/Akt inhibition decreases oxygen consumption In tumor cells by phosphorylating and inactivating pyruvate dehydrogenase PDH E1a subunit Proceedings of the american association for cancer research annual meeting : 2015.
Rech AJ, Twyman-Saint Victor C, Maity A, Rengan R, Pauken KE, Stelekati E, Benci J, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma D, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Minn AJ, Vonderheide RH: Radiation and dual immune checkpoint blockade overcome tumor resistance and distinctly improve immunity Proceedings of the american association for cancer research annual meeting : 2015.
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