Description of Research Expertise:
My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
My clinical research focuses on using hypofractionated radiation to potentiate the action of immune checkpoint inhibitors in patient with metastatic solid tumors including melanoma, non small-lung cancer, and breast cancer.
Cerniglia George J, Dey Souvik, Gallagher-Colombo Shannon M, Daurio Natalie A, Tuttle Stephen, Busch Theresa M, Lin Alexander, Sun Ramon, Esipova Tatiana V, Vinogradov Sergei A, Denko Nicholas, Koumenis Constantinos, Maity Amit: The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1a Phosphorylation. Molecular cancer therapeutics 14 (8): 1928-38,2015.
Hill-Kayser Christine E, Gabriel Peter, Volz Edna, Lustig Robert A, Tochner Zelig, Hahn Stephen M, Maity Amit: Factors associated with event reporting in the pediatric radiation oncology population using an electronic incident reporting system. Practical radiation oncology : 2015.
Lin Alexander, Maity Amit: Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand. Clinical cancer research : an official journal of the American Association for Cancer Research 21 (9): 1995-2000,2015.
Gabriel Peter E, Volz Edna, Bergendahl Howard W, Burke Sean V, Solberg Timothy D, Maity Amit, Hahn Stephen M: Incident learning in pursuit of high reliability: implementing a comprehensive, low-threshold reporting program in a large, multisite radiation oncology department. Joint Commission journal on quality and patient safety / Joint Commission Resources 41 (4): 160-8,2015.
Gandhi SJ, Minn A, Vonderheide RH, Wherry EJ, Hahn SM, Maity A: Awakening the immune system with radiation: Optimal dose and fractionation. Cancer letters : 2015.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ: Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature : 2015.
Descaris c, Woodhouse K, Volz E, Gabriel P, Suneja G, Maity A, Hahn S: Examining Patient Perceptions of Quality and Safety in a Large Radiation Oncology Department 2015 American Society for Radiation Oncology (ASTRO) Annual Meeting, poster presentation : 2015.
Rech AJ, Twyman-Saint Victor C, Maity A, Rengan R, Pauken KE, Stelekati E, Benci J, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma D, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Minn AJ, Vonderheide RH: Radiation and dual immune checkpoint blockade overcome tumor resistance and distinctly improve immunity Proceedings of the american association for cancer research annual meeting : 2015.
Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio N, Tuttle S, Busch TM, Lin A, Esipova TV, Vinogradov SA, Koumenis C, Maity A: PI3K/Akt inhibition decreases oxygen consumption In tumor cells by phosphorylating and inactivating pyruvate dehydrogenase PDH E1a subunit Proceedings of the american association for cancer research annual meeting : 2015.
Woodhouse K, Volz E, Bellerive M, Gabriel P, Maity A, Hahn S, Vapiwala N: The Implementation and Assessment of a Quality and Safety Culture Education Program in a Large Radiation Oncology Department 2015 American Society for Radiation Oncology (ASTRO) Annual Meeting, poster presentation : 2015.
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