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Amy S. Clark, MD, MSCE

Amy S. Clark, MD, MSCE Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Clark is a Penn Medicine employed physician.

Clinical Specialties


  • Medicine
    • Medical Oncology

Programs & Services:

  • Cancer
    • Breast Cancer
  • LGBT Health

Board Certification:

  • Internal Medicine, 2009
  • Medical Oncology, 2012

Conditions & Treatments:

  • Breast Cancer
  • breast exam
  • Cancer Clinical Trials
  • cancer therapy
  • Ductal Carcinoma in Situ (DCIS)
  • Inflammatory Breast Cancer (IBC)
  • Invasive (Infiltrating) Ductal Carcinoma (IDC)
  • Invasive (Infiltrating) Lobular Carcinoma (ILC)
  • lesbian, gay and bisexual health (LGBT)
  • Male Breast Cancer
  • Other types of Breast Cancer
  • Triple-Negative Breast Cancer

Clinical Interests

I am a medical oncologist who specializes in breast cancer. I only see breast cancer patients in the outpatient setting, but treat patients will all cancers when working in the hospital.

Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Penn State Milton S. Hershey Medical Center
Residency: Boston Medical Center (Formerly Boston City Hospital)
Fellowship: Hospital of the University of Pennsylvania


American Society of Clinical Oncology, National


Dr. Clark is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Research Interests:

My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.

Selected Publications:

DeMichele Angela, Yee Douglas, Berry Donald A, Albain Kathy S, Benz Christopher C, Boughey Judy, Buxton Meredith, Chia Stephen K, Chien A Jo, Chui Stephen Y, Clark Amy, Edmiston Kirsten, Elias Anthony, Forero-Torres Andres, Haddad Tufia C, Haley Barbara, Haluska Paul, Hylton Nola M, Isaacs Claudine, Kaplan Henry, Korde Larissa A, Leyland-Jones Brian, Liu Minetta C, Melisko Michelle, Minton Susan E, Moulder Stacy, Nanda Rita, Olopade Olufunmilayo I, Paoloni Melissa, Park John W, Parker Barbara A, Perlmutter : The Neoadjuvant Model is Still the Future for Drug Development in Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research : 2015.

Silber Jeffrey H, Rosenbaum Paul R, Ross Richard N, Niknam Bijan A, Ludwig Justin M, Wang Wei, Clark Amy S, Fox Kevin R, Wang Min, Even-Shoshan Orit, Giantonio Bruce J: Racial disparities in colon cancer survival: a matched cohort study. Annals of internal medicine 161 (12): 845-54,2014.

DeMichele Angela, Clark Amy, Tan Kay S, Heitjan Daniel F, Gramlich Kristi, Gallagher Maryann, Lal Priti, Feldman Michael, Zhang Paul, Colameco Christopher, Lewis David, Langer Melissa, Goodman Noah, Domchek Susan M, Gogineni Keerthi, Rosen Mark, Fox Kevin R, O'Dwyer Peter: CDK 4/6 Inhibitor Palbociclib (PD0332991) in Rb+ Advanced Breast Cancer: Phase II Activity, Safety and Predictive Biomarker Assessment. Clinical cancer research : an official journal of the American Association for Cancer Research : 2014.

Clark Amy S, Chen Jinbo, Kapoor Shiv, Friedman Claire, Mies Carolyn, Esserman Laura, DeMichele Angela: Pretreatment vitamin D level and response to neoadjuvant chemotherapy in women with breast cancer on the I-SPY trial (CALGB 150007/150015/ACRIN6657). Cancer medicine 3 (3): 693-701,2014.

Clark Amy S, McDonald Elizabeth, Lynch M Camilla, Mankoff David: Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer. Oncology (Williston Park, N.Y.) 28 (5): 424-30,2014.

Mankoff David A, Pryma Daniel A, Clark Amy S: Molecular imaging biomarkers for oncology clinical trials. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 55 (4): 525-8,2014.

Clark, AS, O’Dwyer P, Heitjen, D, Lal, P, Feldman, M, Gallagher, M, Redlinger, C, Colameco, C, Lewis, D, Zafman, K, Langer, M, Rosen, M, Gogineni, K, Bradbury, A, Domchek, S, Fox, K, DeMichele, A.: A Phase I Trial of Palbociclib and Paclitaxel in Metastatic Breast Cancer. Proceedings of the American Society of Clinical Oncology : 2014.

15. DeMichele, A, Dickson, M, Clark, AS, Colameco, C, Gallagher, M, Gramlich, K, Zafman, K, Lewis, D, Vaughn, D, Schwartz, G, O’Dwyer, P.: Characterization of Isolated, Uncomplicated Neutropenia, Related to the CDK 4/6 Inhibitor Palbociclib. Proceedings of the American Society of Clinical Oncology : 2014.

Silber Jeffrey H, Rosenbaum Paul R, Clark Amy S, Giantonio Bruce J, Ross Richard N, Teng Yun, Wang Min, Niknam Bijan A, Ludwig Justin M, Wang Wei, Even-Shoshan Orit, Fox Kevin R: Characteristics associated with differences in survival among black and white women with breast cancer. JAMA 310 (4): 389-97,2013.

Clark, AS, Lal, P, Tan KS, Heitjan, D, Lunceford, N, Feldman M, Zhang, P, Gallagher, M, Gramlich, K, Domchek, S, Gogineni, K, Keefe, S, Fox, KR, O’Dwyer, P, DeMichele, A.: Biomarkers to Predict Response to PD 0332991, an Oral CDK 4/6 Inhibitor: Examination in Patients with Metastatic Breast Cancer Enrolled on UPCC 03909. San Antonio Breast Cancer Symposium : 2013.

Academic Contact Info

Perelman Center for Advanced Medicine
3rd Floor, West Pavilion
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 662-7096
Fax: (215) 615-3349
Patient appointments: 800-789-PENN (7366)