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Donald M. O'Rourke, MD Surgeon

Director, Human Brain Tumor Tissue Bank
Associate Professor of Neurosurgery

Dr. O'Rourke is a Penn Medicine employed physician.

About Dr. Donald M. O'Rourke

Recognized annually in Philadelphia Magazine's Top Docs issue from 2005 through 2015

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties


  • Neurosurgery

Programs & Centers:

  • Cancer
    • Brain and Spinal Cord Tumors Program
  • Neurosurgery

Board Certification:

  • Neurological Surgery, 1998

Clinical Expertise:

  • Arnold-Chiari malformation
  • astrocytoma
  • Brain Cancer
  • brain cancer - metastasis
  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • cancer – neuro oncology
  • cancer skull base
  • Cancer Surgery
  • cervical degenerative disease
  • cervical myelopathy
  • cervical spine surgery
  • Gamma Knife radiosurgery
  • Glioma
  • lumbar degenerative disease
  • meningioma
  • Metastasis Cancer
  • Spinal Cord Cancer
  • Spinal Stenosis
  • Spinal Tumor
  • spine disorders
  • spine microsurgery
  • Spondylosis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American Association for the Advancement of Science, National American Association of Neurological Surgeons Research Foundation, National American Association of Neurological Surgeons, National Congress of Neurological Surgeons, National Department of Veterans Affairs, Merit Review Program, Department of Medical Research, National Fellow, College of Physicians of Philadelphia, Local National Institutes of Health, National Cancer Insitute Brain Cancer Review Cluster, National Osler Institute, Annual Neurosurgery Oral Board Review Course, National Pediatric Brain Tumor Consortium, National Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Section on Tumors, American Association of Neurological Surgeons and Congress of Neurological Surgeons, National Society for Neuro-Oncology, National Society for Neuroscience, National The Wellcome Trust, United Kingdom, Scientific Review Committee, International

Hospital Affiliation

Dr. O'Rourke is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Walsh Alice M, Kapoor Gurpreet S, Buonato Janine M, Mathew Lijoy K, Bi Yingtao, Davuluri Ramana V, Martinez-Lage Maria, Simon M Celeste, O'Rourke Donald M, Lazzara Matthew J: Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Molecular cancer research : MCR : 2015.

Çoban G, Mohan S, Kural F, Wang S, O'Rourke D M, Poptani H: Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas. AJNR. American journal of neuroradiology : 2015.

Jabehdar Maralani Pejman, Melhem Elias R, Wang Sumei, Herskovits Edward H, Voluck Matthew R, Kim Sang Joon, Learned Kim O, O'Rourke Donald M, Mohan Suyash: Association of dynamic susceptibility contrast enhanced MR Perfusion parameters with prognosis in elderly patients with glioblastomas. European radiology : 2015.

Abdullah Kalil G, Ramayya Ashwin, Thawani Jayesh P, Macyszyn Lukasz, Martinez-Lage Maria, O'Rourke Donald M, Brem Steven: Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. PloS one 10 (5): e0127202,2015.

Ojerholm Eric, Lee John Y K, Thawani Jayesh P, Miller Denise, O'Rourke Donald M, Dorsey Jay F, Geiger Geoffrey A, Nagda Suneel, Kolker James D, Lustig Robert A, Alonso-Basanta Michelle: Stereotactic radiosurgery to the resection bed for intracranial metastases and risk of leptomeningeal carcinomatosis. Journal of neurosurgery 121 Suppl : 75-83,2014.

Akbari Hamed, Macyszyn Luke, Da Xiao, Wolf Ronald L, Bilello Michel, Verma Ragini, O'Rourke Donald M, Davatzikos Christos: Pattern analysis of dynamic susceptibility contrast-enhanced MR imaging demonstrates peritumoral tissue heterogeneity. Radiology 273 (2): 502-10,2014.

Wang S, Kim S J, Poptani H, Woo J H, Mohan S, Jin R, Voluck M R, O'Rourke D M, Wolf R L, Melhem E R, Kim S: Diagnostic utility of diffusion tensor imaging in differentiating glioblastomas from brain metastases. AJNR. American journal of neuroradiology 35 (5): 928-34,2014.

Pal Sharmistha, Bi Yingtao, Macyszyn Luke, Showe Louise C, O'Rourke Donald M, Davuluri Ramana V: Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. Nucleic acids research 42 (8): e64,2014.

Delfin Gail, Leary Marion, Perman Sarah M, O'Rourke Donald M, Levine Joshua M, Abella Benjamin S: Postarrest targeted temperature management immediately following craniotomy-a case report. Therapeutic hypothermia and temperature management 3 (3): 143-6,2013.

Chawla S, Krejza J, Vossough A, Zhang Y, Kapoor G S, Wang S, O'Rourke D M, Melhem E R, Poptani H: Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy. AJNR. American journal of neuroradiology 34 (8): 1542-9,2013.

Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3490
Fax: (215) 349-5534
Patient appointments: 800-789-PENN (7366)

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