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Donald L. Siegel, MD, PhD

Donald L. Siegel, MD, PhD Physician

Director, Division of Transfusion Medicine and Therapeutic Pathology
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Siegel is a Penn Medicine employed physician.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Services:

  • Cancer
    • Bone Marrow Transplant and Stem Cell Transplant Program
    • Hematological Malignancies (Blood Cancer) Program
  • Pathology and Laboratory Medicine
    • Immunobiology and Experimental Pathology
    • Transfusion Medicine and Therapeutic Pathology

Board Certification:

  • Pathology, 1992

Conditions & Treatments:

  • blood banking
  • Blood Cancer
  • Bone Marrow and Stem Cell Transplantation
  • Bone Marrow Diseases
  • Cancer Screening and Diagnostics
  • hematopoietic stem cell collection and processing
  • immunohematology
  • monoclonal antibody therapy
  • therapeutic apheresis

Clinical Interests

transfusion medicine, blood banking, apheresis, hematopoietic stem cell collection/processing

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association for Cell Biology, National American Association of Blood Banks, National American Society for Apheresis, National American Society of Hematology, National Clinical Applications and Standards Committee, American Society for Apheresis, National Executive Committee of the Medical Advisory Board, Penn-Jersey Division of the American Red Cross, Local FDA Workshop on Molecular Methods in Transfusion Medicine, National Hema-Quebec, Quebec City, Canada, International Hema-Quebec, Quebec City, Canada, International John Morgan Society, Local Medical Advisory Committee, Penn-Jersey Division of the American Red Cross, Local NIH Hematology Small Business Activities [SBIR/STTR] Special Emphasis Panel, National NIH NHLBI Strategic Planning Meeting "Research in Global Blood Safety and Availability, Domestic and International", International NIH Study Section "Selected Topics in Transfusion Medicine" (ZRG1 VH-E 50R), National NIH, Member, Selected Topics in Transfusion Medicine Study Section, National NIH, National NIH/AABB-Sponsored Scientific Think Tank on "Setting the Research Agenda for Immunobiology in Transfusion Medicine", National Scientific Review Panel, Program Project on Prion Diseases, National Institute on Aging, National Scientific Subsection Committee, American Association of Blood Banks, National


Dr. Siegel is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Research Interests:

Research Interests

Production and characterization of pathogenic human monoclonal auto- and alloantibodies

Research Summary

My laboratory is interested in characterizing the human immune response to auto- and alloantigens on a molecular level in order to understand more about human immune repertoire development. Our goal is to use this information to develop specific therapeutic agents that down-regulate immune responses in the settings of autoimmune disease such as immune hemolytic anemias and thrombocytopenias, transfusion reactions, hemolytic disease of the newborn, and acute rejection of solid organ allografts.
To approach these problems experimentally, we have combined Fab/phage-display technology with a novel cell-surface panning method to isolate large arrays of clinically significant human monoclonal antibodies from individual patients. This approach has enabled us to study the genetic and immunological properties of pathogenic auto- and alloantibodies.

Selected Publications:

Villa CH., Pan DC., Zaitsev S., Cines D.B., Siegel D.L., Muzykantov, V.R.: Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier Therapeutic Delivery 6 : 795-826,2015.

Rapoport, A.P., Stadtmauer, E.A., Binder-Scholl, G.K., Goloubeva, O., Vogl, D.Y., Lacey, S., Badros, A.Z., Garfall, A., Weiss, B., Finklestein, J., Kulikovskaya, I., Sinha, S.K., Kronsberg, S., Gupta, M., Bond, S., Melchiori, L., Brewer, J.E., Bennett, A.D., Gerry, A.B., Pumphrey, N.J., Williams, D., Tayton-Martin, H.K., Ribeiro, L., Holdich, T., Yanovich, S., Hardy, N., Yared, J., Kerr, N., Philip, S., Westphal, S., Siegel, D.L., Levine, B.L., Jakobsen, B.K., Kalos, M., June, C.H.: NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma Nature Medicine 21 : 914-921,2015.

Polak, K., Acierno, M., Raj, K., Mizukamo, K., Siegel, D.L., Giger, U: Dog Erythrocyte Antigen 1 (DEA 1): Mode of inheritance and initial characterization Veterinary Clinical Pathology doi: 10.1111/vcp.1228 : 2015.

Pickens, B., Mao, Y., Li, D., Siegel, D.L., Poncz, M., Cines, D.B., Zheng, X.L.: Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models Blood 125 : 3326-34,2015.

Casina, V.C., Hu, W., Mao, J., Lu, R.-N., Hanby, H.A., Pickens, B., Kan, Z., Lim, W.K., Mayne, L., Ostertag, E., Kacir, S., Siegel, D.L., Englander, S.W., Zheng, X.L.: High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome Proc Natl Acad Sci (USA) 112 : 9620-9625,2015.

Siegel D.L., Westhoff, C: Rh and LW Blood Groups Rossi’s Principles of Transfusion Medicine : 2015.

Zhao A., Tohidkia M.R., Siegel D.L., Coukos G., Omidi Y.: Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy Critical Reviews in Biotechnology 10.3109/07388551.2014.958978 : 1-14,2015.

Hammers, C.M., Chen, J., Lin, C., Kacir, S., Siegel, D.L., Payne, A.S., Stanley, J.R.: Persistence of anti-desmoglein 3 IgG+ B-cell clones in pemphigus patients over years J Invest Dermatol 135 : 742-749,2015.

Gao, C., Liu, Y., Zhang, H., Zhang, Y., Fukuda, M.N., Palma, A.S., Kozak, R.P., Childs, R.A., Nonaka, M., Li, Z., Siegel, D.L., Hanfland, P., Peehl, D.M., Chai, W., Greene, M.I., Feizi, T.: Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array J. Biol. Chem. 289 : 16462-16477,2014.

Azzato E., Gentile C., Carpenter H., Siegel D., Watt C.: Successful red blood cell gemotyping from leukoreduced packed red blood cell segments abstracts of the 2014 Annual Meeting of the Association for Molecular Pathology : 2014.

View all publications

Academic Contact Info

510 Stellar-Chance Laboratories
422 Curie Blvd.

Philadelphia, PA 19104
Phone: (215) 898-9655

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