I conduct brain tumor research and specialize in treatment of patients with intracranial malignancies. I have scientific expertise in the areas of signal transduction, molecular therapeutics, brain tumor biology, and radiation biology. As a translational researcher, I am actively involved in basic mechanistic studies, the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer, and early phase clinical trials in intracranial malignancies (as lead principal investigator). In a broad sense, my research focuses on understanding the underlying mechanisms whereby cancers demonstrate resistance to radiation and chemotherapy and characterizing normal cell/tissue responses to radiation therapy. This information will give us a framework to develop ways to target oncogenic pathways that lead to therapeutic resistance and identify potential molecular interventions that may reduce the normal tissue complications of radiation therapy. One major focus concerns the elucidation of the mechanism whereby ER stress modulates death receptor expression and initiation of apoptosis. A second area of interest is the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer with a focus on high-grade brain tumor biology. This includes evaluation of the efficacy of novel therapeutic combinations in preclinical animal models and determination of timing, dosage, and in vivo mechanisms of anti-tumor action. In summary, I have a demonstrated record of successful and productive research projects in highly relevant areas of cancer, molecular oncology, and radiation biology.
McQuade C, Al Zaki A, Desai Y, Vido M, Sakhuja T, Cheng Z, Hickey RJ, Joh D, Park SJ, Kao G, Dorsey JF, Tsourkas A.: A Multifunctional Nanoplatform for Imaging, Radiotherapy, and the Prediction of Therapeutic Response. SMALL : 2014.
Dorsey JF, Kao GD, MacArthur KM, Ju M, Steinmetz D, Wileyto EP, Simone CB 2nd, Hahn SM.: Tracking viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer patients undergoing definitive radiation therapy: Pilot study results. CANCER : 2014.
Ju M, Kao G, Christodouleas J, Guzzo T, Keefe S, Hahn SM, Dorsey JF: Application of a Telomerase-based Circulating Tumor Cell (CTC) assay in bladder cancer patients receiving post-operative Radiation Therapy: A case study CANCER BIOLOGY & THERAPY 15 (6): 2014.
Ojerholm E, Lee JYK, Kolker J, Dorsey JF, Alonso-Basanta M: Gamma knife radiosurgery to 4 or more brain metastases in patients without prior intracranial radiation or surgery. CANCER MEDICINE 3 (3): 565-71,2014.
MacArthur KM, Kao GD, Chandrasekaran S, Alonso-Basanta M, Chapman C, Lustig RA, Wileyto EP, Hahn SM, Dorsey JF: Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay CANCER RESEARCH 74 (8): 2152-9,2014.
Yang W, Cooke M, Duckett C, Yang X, Dorsey JF: Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells CELL CYCLE 13 (6): 1-14,2014.
Al Zaki A, Joh D, Cheng Z, de Barros AL, Kao G, Dorsey J, Tsourkas A: Gold-Loaded Polymeric Micelles for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization. ACS NANO 8 (1): 104-112,2014.
Alonso-Basanta M, Fang P, Hahn SM, Lustig RA, Dorsey JF: A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme JOURNAL OF NEUROONCOLOGY 116 (2): 365-72,2014.
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