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John P. Plastaras, MD

John P. Plastaras, MD Physician

Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Dr. Plastaras is a Penn Medicine employed physician.

Clinical Specialties


  • Radiation Oncology

Programs & Centers:

  • Cancer
    • Gastrointestinal Cancer Program
    • Lymphoma Program
  • Radiation Oncology
    • Gastrointestinal Cancer

Board Certification:

  • Radiation Oncology, 2008

Clinical Expertise:

  • Anal Cancer
  • Bile Duct Cancer
  • Blood Cancer
  • Cancer Clinical Trials
  • Cancer Pain
  • Cancer Therapy
  • Colon Cancer
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Carcinoid Tumor
  • Liver Cancer
  • Lymphoma
  • Multimodal Therapy (MMT)
  • Neuroendocrine Tumors
  • Non-Hodgkin Lymphoma
  • Pancreatic Cancer
  • radiation oncology - bone marrow transplant
  • radiation oncology - gastroenterology
  • Radiation Treatment
  • Rectal Cancer
  • Small Intestine Cancer
  • Stomach (Gastric) Cancer

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Vanderbilt University
Residency: Memorial Sloan-Kettering Cancer Center
Residency: Hospital of the University of Pennsylvania


American Association of Cancer Research, National American Board of Radiology, National American College of Radiology, National American Society for Radiation Oncology (ASTRO), National American Society of Clinical Oncology, National Council of Affiliated Regional Radiation Oncology Societies, National Pennsylvania Radiological Society, Local Philadelphia Roentgen Ray Society, Local Radiation Research Society, National Radiologic Society of North America, National

Hospital Affiliation

Dr. Plastaras is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" ( Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" ( Identifier: NCT01449864)

Selected Publications:

Datta Jashodeep, McMillan Matthew T, Ecker Brett L, Karakousis Giorgos C, Mamtani Ronac, Plastaras John P, Giantonio Bruce J, Drebin Jeffrey A, Dempsey Daniel T, Fraker Douglas L, Roses Robert E: Implications of Lymph Node Staging on Selection of Adjuvant Therapy for Gastric Cancer in the United States: A Propensity Score-matched Analysis. Annals of surgery : 2015.

McMillan Matthew T, Ojerholm Eric, Roses Robert E, Plastaras John P, Metz James M, Mamtani Ronac, Karakousis Giorgos C, Fraker Douglas L, Drebin Jeffrey A, Stripp Diana, Ben-Josef Edgar, Datta Jashodeep: Adjuvant Radiation Therapy Treatment Time Impacts Overall Survival in Gastric Cancer. International journal of radiation oncology, biology, physics : 2015.

Datta Jashodeep, McMillan Matthew T, Shang Eric K, Mamtani Ronac, Lewis Russell S, Kelz Rachel R, Teitelbaum Ursina, Plastaras John P, Drebin Jeffrey A, Fraker Douglas L, Karakousis Giorgos C, Roses Robert E: Omission of adjuvant therapy after gastric cancer resection: development of a validated risk model. Journal of the National Comprehensive Cancer Network : JNCCN 13 (5): 531-41,2015.

Fernandes Annemarie T, Apisarnthanarax Smith, Yin Lingshu, Zou Wei, Rosen Mark, Plastaras John P, Ben-Josef Edgar, Metz James M, Teo Boon-Keng: Comparative assessment of liver tumor motion using cine-magnetic resonance imaging versus 4-dimensional computed tomography. International journal of radiation oncology, biology, physics 91 (5): 1034-40,2015.

Ojerholm E, Kirk M, Thompson R, Zhai A, Metz JM, Both S, Ben-Josef E, Plastaras JP: Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy. Acta Oncologica [Epub ahead of print] : 2015.

Zeng C, Plastaras JP, Tochner Z, White B, Hill-Kayser C, Hahn S, Both S: Proton pencil beam scanning for mediastinal lymphoma: the impact of interplay between target motion and beam scanning Physics in Medicine and Biology 60 : 3013-3029,2015.

Gandhi SJ, Liang X, Ding X, Zhu TC, Ben-Josef E, Plastaras JP, Metz JM, Both S, Apisarnthanarax S: Clinical decision tool for optimal delivery of liver stereotactic body radiation therapy (SBRT): photons versus protons Practical Radiation Oncology in press : 2015.

Landsburg DJ, Vogl DT, Plastaras JP, Stadtmauer EA: Melphalan/total body irradiation-conditioned myeloablative allogeneic hematopoietic cell transplantation for patients with primary plasma cell leukemia Clinical Lymphoma, Myeloma & Leukemia 14 (6): e225-8,2014.

Dionisi F, Avery S, Lukens JN, Ding X, Kralik J, Kirk M, Roses RE, Amichetti M, Metz JM, Plastaras JP: Proton therapy in adjuvant treatment of gastric cancer: planning comparison with advanced x-ray therapy and feasibility report Acta Oncologica 53 (10): 1312-20,2014.

Bloch P and Plastaras JP: Dose Calculation for I131/ I124 Radioimmunoconjugates for Radioimmunotherapy Austin Journal of Nuclear Medicine and Radiotherapy 1 (1): 3,2014.

Academic Contact Info

Department of Radiation Oncology
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 615-3714
Fax: (215) 349-8975
Patient appointments: 800-789-PENN (7366)

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