1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.
2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.
3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.
4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)
Fernandes Annemarie T, Apisarnthanarax Smith, Yin Lingshu, Zou Wei, Rosen Mark, Plastaras John P, Ben-Josef Edgar, Metz James M, Teo Boon-Keng: Comparative assessment of liver tumor motion using cine-magnetic resonance imaging versus 4-dimensional computed tomography. International journal of radiation oncology, biology, physics 91 (5): 1034-40,2015.
Ojerholm E, Kirk M, Thompson R, Zhai A, Metz JM, Both S, Ben-Josef E, Plastaras JP: Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy. Acta Oncologica [Epub ahead of print] : 2015.
Gandhi SJ, Liang X, Ding X, Zhu TC, Ben-Josef E, Plastaras JP, Metz JM, Both S, Apisarnthanarax S: Clinical decision tool for optimal delivery of liver stereotactic body radiation therapy (SBRT): photons versus protons Practical Radiation Oncology in press : 2015.
Zeng C, Plastaras JP, Tochner Z, White B, Hill-Kayser C, Hahn S, Both S: Proton pencil beam scanning for mediastinal lymphoma: the impact of interplay between target motion and beam scanning Physics in Medicine and Biology 60 : 3013-3029,2015.
Landsburg DJ, Vogl DT, Plastaras JP, Stadtmauer EA: Melphalan/total body irradiation-conditioned myeloablative allogeneic hematopoietic cell transplantation for patients with primary plasma cell leukemia Clinical Lymphoma, Myeloma & Leukemia 14 (6): e225-8,2014.
Dionisi F, Avery S, Lukens JN, Ding X, Kralik J, Kirk M, Roses RE, Amichetti M, Metz JM, Plastaras JP: Proton therapy in adjuvant treatment of gastric cancer: planning comparison with advanced x-ray therapy and feasibility report Acta Oncologica 53 (10): 1312-20,2014.
Bloch P and Plastaras JP: Dose Calculation for I131/ I124 Radioimmunoconjugates for
Radioimmunotherapy Austin Journal of Nuclear Medicine and Radiotherapy 1 (1): 3,2014.