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Jonathan P. Katz, MD

Jonathan P. Katz, MD Physician

Associate Professor of Medicine

Dr. Katz is a Penn Medicine employed physician.

Clinical Specialties


  • Medicine
    • Gastroenterology

Programs & Services:

  • Gastroenterology
    • General Gastroenterology Consultation

Board Certification:

  • Gastroenterology, 1998

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Chicago School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


AGA Augustyn Award Panel, National AGA Institute, Research Awards Panel, National American Association for Cancer Research, International American Association for the Advancement of Science, National American Gastroenterological Association, National American Gastroenterological Association, Trainee and Young GI Policy Council, National Cancer Research UK, International DDW Abstract Review Committee, International Gastroenterology Research Group, National Health Research Board (HRB), Ireland, International Medical Research Council (MRC), Great Britain, International Medical Research Council (MRC), Molecular and Cellular Medicine Board (MCMB), Great Britain, International Molecular and Cellular Oncology P01 Special Emphasis Panel, National NCI Cellular and Molecular Biology P01 Cluster Grant Review Panel, National NIDDK DDK-C Study Section, National NIDDK P01 Special Emphasis Panel, National NIDDK Silvio O. Conte Digestive Diseases Research Core Centers P30 Special Emphasis Panel, National NIDDK Silvio O. Conte Digestive Diseases Research Core Centers P30 Special Emphasis Panel, National NIH ZRG1 CB-J (30) Study Section, National NIH ZRG1 DKUS C Special Emphasis Panel, National Pilot Projects, New England Medical Center, Center for Gastroenterology Research on Absorptive and Secretory Processes (GRASP), National Pilot Projects, University of Pennsylvania, Center for Molecular Studies in Digestive and Liver Diseases, Local Wellcome Trust, International


Dr. Katz is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Research Interests:

Research Interests
Transcriptional regulation
Epithelial homeostasis
Gastrointestinal carcinogenesis

Key words: gastrointestinal cancer, Krüppel-like factors, proliferation, differentiation

Description of Research
My research focuses on analyses of gastrointestinal proliferation, differentiation, and malignant transformation. Recently, my laboratory has concentrated on KLF4 and KLF5, two related Krüppel-like factor (KLF) family members highly expressed in the gastrointestinal epithelia. KLF4 and KLF5 are important regulators of cellular proliferation and differentiation both in vitro and in vivo. Numerous studies implicate these factors in carcinogenesis in a number of tissues and cell types. Using tissue-specific gene ablation and transgenic approaches, we have generated a number of mouse models to investigate the function of Klf4 and Klf5 in development and gastrointestinal epithelial homeostasis in vivo. These mouse models are complemented by novel in vitro model systems, using primary esophageal cells in two-dimensional culture and three-dimensional organotypic culture. These experiments allow us to dissect the molecular mechanisms regulating gastrointestinal epithelial homeostasis, including the role of epithelial-mesenchymal interactions. Using these in vitro and in vivo models, we are examining the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis.

Rotation Projects
Several rotation projects are available in the laboratory based upon applicant interests. Please contact Dr. Katz directly to discuss potential projects.

Lab personnel:
Jonathan Katz, MD – Principal Investigator
Yizeng Yang, MD, PhD - Senior Research Investigator
Marie-Pier Tetreault, PhD - Research Associate
Daniel Weinblatt - Research Specialist

Administrative Assistant:
Hayley Sharpe
Phone: 215-898-0850

Selected Publications:

Tetreault, M.P., Yang, Y., Katz, J.P: Krüppel-like factors in cancer. Nature Reviews Cancer 13 (10): 701-13,2013.

Tarapore, R.S., Yang, Y., Katz, J.P.: Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival. Neoplasia 15 (5): 472-80,2013.

Yang, Y., Tarapore, R.S., Jarmel, M.H., Tetreault, M.P., Katz, J.P.: p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle 11 (21): 2012.

Tetreault, M.P., Alrabaa, R., McGeehan, M., Katz, J.P.: Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One 7 (5): e38338,2012.

Yang, Y., Nakagawa, H., Tetreault, M.P., Billig, J., Victor, N., Goyal, A., Sepulveda, A.R., Katz, J.P.: Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Research 71 (20): 6475-84,2011.

Tetreault, M.P., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Tobias, J.W., Katz, J.P.: Esophageal squamous cell dysplasia and delayed differentiation with deletion of Krüppel-like factor 4 in murine esophagus. Gastroenterology 139 (1): 171-81.e9,2010.

Tetreault, M.P., Wang, M.L., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Katz, J.P.: Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology 139 (6): 2124-2134.e9,2010.

Yang, Y., Tetreault, M.P., Yermolina, Y., Goldstein, B.G., Katz, J.P.: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. Journal of Biological Chemistry 283 : 18812-20,2008.

Yang, Y., Goldstein, B.G., Nakagawa, H., Katz, J.P.: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 21 : 543-50,2007.

Yang, Y., Goldstein, B.G., Chao, H., Katz, J.P.: KLF4 and KLF5 regulate proliferation, apoptosis, and invasion in esophageal cancer cells. Cancer Biology and Therapy 4 : 1216-21,2005.

View all publications

Academic Contact Info

913 Biomedical Research Building II/III
421 Curie Boulevard

Philadelphia, PA 19104-4863
Phone: (215) 746-7780
Fax: (215) 573-2024

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