1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.
2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
Sanzari JK, Wan XS, Wroe AJ, Rightnar S, Cengel KA, Diffenderfer ES, Krigsfeld GS, Gridley DS, Kennedy AR: Acute Hematological Effects of Solar Particle Event Proton Radiation in the Porcine Model. Radiat Res. 180 (1): 7-16,2013.
Whaley JT, Kirk M, Cengel K, McDonough J, Bekelman J, Christodouleas JP: Protective Effect of Transparent Film Dressing on Proton Therapy Induced Skin Reactions. Radiat Oncol. 8 : 19,2013.
Cengel KA, Sanzari J, Billings P, Diffenderfer ES, Kennedy AR: Evaluating Radiation Repose And Countermeasures For Exposure To
Solar Particle Events With Differing Energy-Fluence Profiles. Heavy Ion in Therapy and Space Radiation Symposium 2013, Chiba, Japan : 2013.
Cengel KA, Sanzari J, Billings P, Diffenderfer ES, Kennedy AR: Determining The Whole Body Radiation Repose To Solar Particle Events With Differing Energy-fluence Profiles. NASA Human Research Program Investigator's Workshop, Galveston, TX : 2013.
Cengel KA, Kennedy AR: NSBRI Center For Acute Radiation Research: Dosimetric and Practical Considerations for Simulating Solar Particle Event Exposure for Earth Based Model Systems. National Space Biomedical Research Institute Radiation Effects Team : 2013.
Chandra A, Lan S, Zhu J, Lin T, Zhang X, Siclari VA, Altman AR, Cengel KA, Liu XS, Qin L.: PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone. 55 (2): 449-57,2013.
Pietrofesa R, Turowski J, Tyagi S, Dukes F, Arguiri E, Busch TM, Gallagher-Colombo SM, Solomides CC, Cengel KA, Christofidou-Solomidou M: Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer. 13 : 179,2013.
Edmonds C, Hagan S, Gallagher-Colombo SM, Busch TM, Cengel KA: Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer. Cancer Biol Ther. 13 (14): 1463-70,2012.
Cengel K, Yendamuri S, Demmy T, Culligan M, Schofield M, Smith D, Punekar S, Sterman D, Stevenson J, Busch T, Glatstein E, Hahn S, Friedberg J: Qualitative And Quantitative Differences in the Toxicity Of HPPH-Mediated PDT with a 24 Versus 48-Hour Drug Light Interval: Moving from the Bedside to the Bench and Back. SPIE Photonics West, San Francisco, CA : 2012.
Fishbein L, Bonner L, Torigian DA, Nathanson KL, Cohen DL, Pryma D, Cengel KA: External Beam Radiation Therapy (EBRT) for Patients with Malignant Pheochromocytoma and Non-Head and Neck Paraganglioma: Combination with 131I-MIBG. Horm Metab Res. 44 (5): 405-10,2012.
View all publications