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Kristy L. Weber, MD

Kristy L. Weber, MD Physician

Chief, Orthopaedic Oncology
Director of the Sarcoma Program, Abramson Cancer Center
Professor, Vice-Chair of Faculty Affairs, Department of Orthopaedic Surgery
Abramson Family Professor in Sarcoma Care Excellence

Dr. Weber is a Penn Medicine employed physician.

Clinical Specialties


  • Orthopaedic Surgery

Programs & Services:

  • Cancer
    • Bone Cancer
    • Sarcoma
  • Orthopaedics
    • Orthopaedic Oncology

Board Certification:

  • Orthopaedic Surgery, 2000

Conditions & Treatments:

  • bone biopsy
  • Bone Cancer
  • bone disease - metastatic
  • bone lesions
  • chest wall resection
  • desmoid tumor - non-surgical treatment
  • hand tumors
  • lesions
  • limb salvage - malignancy
  • malignant melanoma
  • muscle biopsy
  • orthopaedic oncology
  • pathologic fracture
  • Sarcoma
  • soft tissue biopsy
  • soft tissue tumor

Clinical Interests

Fellowship trained orthopaedic oncologist specializing in complex limb salvage surgery around the hip/knee/shoulder/pelvis using metal prostheses, structural allografts/vascularized fibular grafts, and biologic reconstructions in skeletally immature patients.

Sees patients of all ages with benign/malignant soft tissue or bone tumors.

Sees patients with metastatic bone disease from other original sites (ie breast, prostate, lung, kidney, thyroid, etc).

Directs a multidisciplinary team including surgeons, radiation oncologists, and medical/pediatric oncologist to take care of patients with musculoskeletal tumors.

Diagnoses bone and soft tissue tumors using image-guided needle biopsies.

Practice Locations and Appointments

  • Penn Orthopaedics

    Perelman Center for Advanced Medicine West Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Johns Hopkins University School of Medicine
Residency: University of Iowa Hospitals and Clinics
Fellowship: Mayo Clinic


American Academy of Orthopaedic Surgeons, National American Board of Orthopaedic Surgery (ABOS), National American College of Radiology, National American Orthopaedic Association, National American Society for Bone and Mineral Research (ASBMR), National Connective Tissue Oncology Society, International International Society of Limb Salvage, International Maryland Orthopaedic Assoication, Local Musculoskeletal Tumor Society, National Orthoapedic Research and Education Foundation (OREF), National Orthopaedic Research Society, National Ruth Jackson Orthopaedic Society, National Twentieth Century Orthopaedic Association, National University of Iowa Department of Orthopaedics Second Century Committee, National


Dr. Weber is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Research Interests:

Specializes in murine models of bone metastasis from breast and kidney.

Additional expertise in osteosarcoma murine models studying local tumor growth in bone and metastasis to the lungs.

Focused on identifying unique molecular targets in both breast and renal cancer.

Utilizes novel drug therapies to treat bone destruction and systemic metastasis in breast and renal cancer murine models.

Selected Publications:

Weber K: Part 4 of a series of interviews with Janet S. Wright, MD, Senior VP of Science and Quality at the American College of Cardiology on Quality Initiatives AAOS Now Podcast : 2014.

Davalos-Bichara M, Lin FR, Carey JP, Walston JD, Fairman JE, Schubert MC, Barron JS, Hughes J, Millar JL, Spar A, Weber KL, Ying HS, Zackowski KM, Zee D, Agrawal Y: Development and Validation of a Falls-Grading Scale. Journal of Geriatric Physical Therapy 36 (2): 63-67,2013.

Mugera C, Belzberg A, Suh KJ, Weber KL, Carrino J, Huisman T, Chabbra A: Sclerotic Lesions of the Spine - MRI Assessment Journal of Magnetic Resonance Imaging : 2013.

Miclau T, Moshed S, Weber KL (Section 1 Editors): Principles of Orthopaedics (Section 1) AAOS Orthopaedic Knowledge Update 11 : 2013.

Turkelson C and Weber KL: The Scientific Foundations of Healthcare Guidelines In Orthopaedic Basic Science: Foundations of Clinical Practice, ed 4. : 2013.

Lau WM, Doucet M, Huang D, Weber KL, Kominsky SL: CITED2 Modulates Estrogen Receptor Transcriptional Activity in Breast Cancer Cells Biochemical and Biophysical Research Communications : 2013.

Weber KL and Kominsky: Concepts and Surgical Treatment of Metastatic Bone Disease. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, (8th ed) : 2013.

Weber, KL: Musculoskeletal Oncology and Systemic Disease AAOS Comprehensive Orthopaedic Review : 2013.

Lau WM, Doucet M, Stadel R, Huang D, Weber KL, Kominsky SL: ENPP1: A Potential Facilitator of Breast Cancer Bone Metastasis PLoS One : 2013.

Del Grande F, Subhawong T, Weber KL, Fayad L: Detection of Soft Tissue Sarcoma Recurrence: Added Value of Functional MR Imaging Techniques at 3T Radiology : 2013.

Academic Contact Info

Hospital of the University of Pennsylvania, 3400 Spruce Street, 2 Silverstein
Philadelphia, PA 19104
Phone: (215) 349-8200
Fax: (215) 349-5890
Patient appointments: 800-789-PENN (7366)

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