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Milton D. Rossman, MD

Milton D. Rossman, MD Physician

Director Interstitial Lung Disease Program
Director, Pulmonary Clinical Immunology Lab
Medical Coordinator Bronchoscopy Service
Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Rossman is a Penn Medicine employed physician.

About Dr. M Rossman

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 - 2008 and 2010 -2015

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Clinical Specialties


  • Medicine
    • Pulmonary Medicine

Programs & Services:

  • Cancer
    • Lung Cancer
  • Lung
    • Interstitial Lung Disease (ILD) and Sarcoidosis

Board Certification:

  • Internal Medicine, 1975
  • Pulmonary Disease, 1978

Conditions & Treatments:

  • beryllium disease
  • Interstitial Lung Disease
  • Lung Cancer
  • Lung Carcinoid Tumor
  • lung disease - occupational
  • Non-Small Cell Lung Cancer
  • Pulmonary Sarcoidosis
  • Small Cell Lung Cancer

Clinical Interests

sarcoidosis, chronic beryllium disease, tuberculosis
Idiopathic pulmonary fibrosis, hypersensistivity pneumonitis, collagne vascular disease associated pulmonary fibrosis.

Practice Locations and Appointments

  • Harron Lung Center

    Perelman Center for Advanced Medicine West Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Jefferson Medical College
Residency: Philadelphia General Hospital
Residency: University Hospitals of Cleveland
Fellowship: Hospital of the University of Pennsylvania


Foundation for Sarcoidosis Research, National National Societies: American Thoracic Society, National National Societies: World Association of Sarcoidosis and Other Granulomatous Diseases, International


Dr. Rossman is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Research Interests:

Research Interests

Identification and functional characterization of inflammatory cells in the normal and abnormal lung, particularly the function of lymphocytes and macrophages in human granulomatous disease.

Research Summary

A primary goal of our research is to understand the mechanisms by which beryllium causes a chronic granulomatous disease. Four approaches to determining the mechanisms of beryllium granulomas are utilized. First, the human T cell lines and clones are being established and the T cell receptors identified and sequenced. Specific subfamilies of T cells appear to be utilized in an oligoclonal response. Second, HLA Class II alleles in patients were identified and compared to exposed but unaffected workers. Not only were specific alleles identified that were associated the beryllium disease, but specific amino acids in hypervariable amino acid positions associated with the binding pockets were found in greater than 90% of cases. Using this information, immortalized B cells from patients with beryllium disease were created and the Class II molecules isolated in the presence and absence of beryllium. Characterization of the peptides bound by these Class II molecules is underway. Initial studies suggest that peptides isolated from HLA Class II DP are able to stimulate beryllium cell lines. Finally, animal models are used to test the importance of specific human proteins in the initiation of the beryllium response and also to determine the nonspecific (adjuvant) effects of beryllium that promote a TH1 or gamma-interferon type response. Similar approaches are being used in other human granulomatous diseases such as sarcoidosis and tuberculosis.

Selected Publications:

Rossman M. Thompson B. Frederick M. Cizman B. Magira E. Monos D: Sarcoidosis: association with human leukocyte antigen class II amino acid epitopes and interaction with environmental exposures Chest 121 (3 Suppl): 14S,2002.

Rosssman MD: Chronic beryllium disease: a hypersensitivity disorder Applied Occupational & Environmental Hygiene 16 (5): 615-18,2001.

Rossman, M.D., MacGregor, R.R.: Tuberculosis: Clinical Management and New Challenges : 1995.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
827 West Gates Building
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3202
Fax: (215) 614-0869
Patient appointments: 800-789-PENN (7366)

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