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Steven Brem, MD Surgeon

Co-Director, Brain Tumor Center
Director of Neurosurgical Oncology
Professor of Neurosurgery at the Hospital of the University of Pennsylvania

Languages spoken:

  • French
  • Spanish

Dr. Brem is a Penn Medicine employed physician.

About Dr. S Brem

Recognized by America's Top Doctors, 2012-14

Clinical Specialties


  • Neurosurgery

Programs & Services:

  • Cancer
    • Brain Metastasis
    • Brain Tumors
    • Spinal Cord Cancer
  • Neurosurgery

Board Certification:

  • Neurological Surgery, 1983

Conditions & Treatments:

  • acoustic neuromas
  • brain cancer
  • brain cancer - metastasis
  • Brain Metastasis
  • Brain Tumors
  • cancer – skull base
  • Cancer Clinical Trials
  • Cancer Surgery
  • Gamma Knife radiosurgery
  • gene therapy - brain
  • glioma
  • meningioma
  • neuro-oncology
  • radiosurgery
  • Spinal Cord Tumors
  • Spondylosis

Clinical Interests

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard Medical School
Residency: Massachusetts General Hospital
Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
Fellowship: University of California, Los Angeles


American Brain Tumor Association, National American College of Surgeons, National Angiogenesis and Invasion Committee, NABTT CNS Brain Tumor Consortium, National Appointed to NCI Comprehensive Cancer Core Grant, National Appointed to NCI Program Project Review Panel, ZCA1 GRB-P, Discovery, Imaging, and Therapeutics, National Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National Brain Tumor Action Network, National Central Brain Tumor Registry of the United States (CBTRUS), National Florida Brain Tumor Research Center (House Bill 1449), National Florida Center for Brain Tumor Research, National International Society of Environmental Toxicology and Cancer, International NABTT Consortium, National Cancer Institute and Participating Medical Centers, National NCI/NIH Review Committee – SPORE Grants for Brain, Head/Neck and Lung Tumors, National NIH / NCI, Brain Tumor Program Project Grant, National NIH / NCI, Clinical Studies Subcommittee D, National Society of Neuro-Oncology, National


Dr. Brem is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Research Interests:

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications:

Coppola Domenico, Balducci Lodovico, Chen Dung-Tsa, Loboda Andrey, Nebozhyn Michael, Staller Aileen, Fulp William J, Dalton William, Yeatman Timothy, Brem Steven: Senescence-Associated-Gene signature identifies genes linked to age, prognosis, and progression of human gliomas. Journal of geriatric oncology : 2014.

Rosenfeld Myrna R, Ye Xiaobu, Supko Jeffrey G, Desideri Serena, Grossman Stuart A, Brem Steven, Mikkelson Tom, Wang Daniel, Chang Yunyoung C, Hu Janice, McAfee Quentin, Fisher Joy, Troxel Andrea B, Piao Shengfu, Heitjan Daniel F, Tan Kay-See, Pontiggia Laura, O'Dwyer Peter J, Davis Lisa E, Amaravadi Ravi K: A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10 (8): 1359-68,2014.

Brem Steven, Meyers Christina A, Palmer Gary, Booth-Jones Margaret, Jain Surbhi, Ewend Matthew G: Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers. Cancer 119 (21): 3830-8,2013.

Chacko Ann-Marie, Li Chunsheng, Pryma Daniel A, Brem Steven, Coukos George, Muzykantov Vladimir: Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert opinion on drug delivery 10 (7): 907-26,2013.

Abdullah Kalil G, Lubelski Daniel, Nucifora Paolo G P, Brem Steven: Use of diffusion tensor imaging in glioma resection. Neurosurgical focus 34 (4): E1,2013.

Nabors L Burt, Mikkelsen Thomas, Hegi Monika E, Ye Xiaubu, Batchelor Tracy, Lesser Glenn, Peereboom David, Rosenfeld Myrna R, Olsen Jeff, Brem Steve, Fisher Joy D, Grossman Stuart A: A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306). Cancer 118 (22): 5601-7,2012.

Xiao Yuanyuan, Decker Paul A, Rice Terri, McCoy Lucie S, Smirnov Ivan, Patoka Joseph S, Hansen Helen M, Wiemels Joe L, Tihan Tarik, Prados Michael D, Chang Susan M, Berger Mitchel S, Kosel Matthew L, Fridley Brooke L, Lachance Daniel H, O'Neill Brian Patrick, Buckner Jan C, Thompson Reid C, Nabors Louis Burt, Olson Jeffrey J, Brem Steve, Madden Melissa H, Browning James E, Wiencke John K, Egan Kathleen M, Jenkins Robert B, Wrensch Margaret R: SSBP2 variants are associated with survival in glioblastoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research 18 (11): 3154-62,2012.

Seaman Brian, Brem Steven, Fromm Allison, Staller Aileen, McCardle Timothy, Jain Surbhi: Intracranial spread of Merkel cell carcinoma to the cerebellopontine angle. Journal of cutaneous medicine and surgery 16 (1): 54-60,2012.

Chinnaiyan Prakash, Chowdhary Sajeel, Potthast Lisa, Prabhu Antony, Tsai Ya-Yu, Sarcar Bhaswati, Kahali Soumen, Brem Steven, Yu H Michael, Rojiani Amyn, Murtagh Ryan, Pan Edward: Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Neuro-oncology 14 (1): 93-100,2012.

Moody Patricia, Murtagh Kevin, Piduru Sarat, Brem Steven, Murtagh Reed, Rojiani Amyn M: Tumor-to-tumor metastasis: pathology and neuroimaging considerations. International journal of clinical and experimental pathology 5 (4): 367-73,2012.

Academic Contact Info

3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery

Philadelphia, PA 19104
Phone: (215) 662-7854
Patient appointments: 800-789-PENN (7366)

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